Biophysical model to correct for blood volume confounders of T2* mapping based renal MR oximetry

Quantitative MRI of renal hypoxia, an early key feature in acute kidney injury, is a valuable tool for diagnostics and pathophysiological studies. En route to MR oximetry we propose a biophysical model that uses the kidney size as an additional MRI derivable information to correct for blood volume confounders of oxygenation sensitive T2* maps. The model is demonstrated in a preclinical study involving three different vascular occlusions highlighting the confounding effect of blood volume changes and its correction.