Extracellular Volume Change in the Human Brain During Sleep: Monitored by MRI-Compatible EEG and Measured by Sodium MRI

Sleep is reported in mince studies to increase extracellular space and improve CSF clearance of amyloid beta proteins from the animal brains. However, it is unclear whether sleep also benefits humans. This study used simultaneous MRI-compatible EEG to monitor sleep stage of human study subjects and used sodium MRI to quantify extracellular volume fraction. We seek to find the association between sleep stage and extracellular volume change in the human brain.