The method of delineating the ROI of whole lesions on quantitative parameter images and then averaging them for comparison did not accurately quantify heterogeneity. In this study, we adopted a habitats analysis method combined with tissue cellularity and blood flow information from IVIM model to segment whole tumor to four subregions to predict microvascular invasion (MVI) in hepatocellular carcinoma. The results show that habitats analysis predicts MVI positivity with an accuracy of 70.19%, and the averaged value of each parameter in whole tumor was not predictive for MVI. This provides a good starting point for further application of this method.
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Li et al. (2024) studied this question.
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