Combined Parkinson’s Disease Related Patterns using ASL MRI and FDG PET

Parkinson's disease-related patterns (PDRPs) of metabolism and perfusion have been reported to reflect brain abnormalities in Parkinson’s disease (PD). However, differences between the glucose metabolism PDRP derived using FDG-PET and the perfusion PDRP derived using ASL have not been compared directly in the same patient cohort. In this work, PDRPs were compared using PET and ASL images of 43 PD patients and 28 health controls using Scaled Subprofile Model analysis. In addition, a new method was proposed to build a multi-modality pattern. Our primary results showed that combined metabolism-perfusion PDRP resulted in superior accuracy than ASL- and PET-derived PDRP alone.