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We investigated the effects of mild sedation with the type A GABA receptor positive allosteric modulator (GABAA-R PAM) midazolam, on cerebral blood flow (CBF), oxygen extraction fraction (OEF) and the rate of cerebral metabolic oxygen consumption (CMRO2) in the healthy human brain using ASL and TRUST MRI. CMRO2 was significantly reduced during sedation compared to wakefulness but no statistically significant change in CBF or OEF was detected. Our data are consistent with prior imaging evidence of reduced brain energy consumption during sedation with midazolam.
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Chandler et al. (2024) studied this question.
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