Motion-corrected quantification of cerebral venous oxygenation in vulnerable populations: from neonates to older adults

Cerebral venous oxygenation (Yv) is a biomarker in various brain diseases such as hypoxic-ischemic-encephalopathy in neonates and Alzheimer's disease in the elderly. T2-Relaxation-Under-Spin-Tagging (TRUST) MRI is a widely used technique to measure global Yv level. However, subject motion during TRUST scan can cause considerable errors in Yv quantification. This work developed an automatic algorithm for motion-corrected quantification of Yv, which showed improved precision of Yv estimation in both neonates and elderly adults.