Many quantitative susceptibility mapping (QSM) studies lack independent reference measurements of susceptibility (χ) for validation. In this work, superconducting quantum interference device (SQUID-) based susceptometry and QSM data were acquired for phantoms with varying manganese chloride (MnCl2) concentrations. χSQUID demonstrated low uncertainty and excellent agreement with the nominal susceptibility values. χQSM and R2* agreed relatively well with the nominal values and previously published results. However, χQSM demonstrated higher uncertainty in comparison to χSQUID. SQUID susceptometry has the potential to identify sources of bias and variability in QSM methods by serving as an independent reference measurement of susceptibility.
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Simchick et al. (2024) studied this question.
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