Predicting IDH1 Expression using Computational Modeling of Interstitial Fluid Pressure in Glioblastoma

The immunohistochemistry features of glioblastoma have important influence on its occurrence and prognosis. Understanding the noninvasive detection of interstitial fluid pressure (IFP) and velocity (IFV) based on dynamic contrast enhanced (DCE)-MRI to explore the correlation between IFP and IFV with immunohistochemical markers of glioblastoma. The investigation demonstrates that IFP indicators have significant correlation with isocitrate dehydrogenase 1 (IDH1) expression and Ki-67 level of glioblastoma, and could help diagnose IDH1-mutation patients.