Magnetic resonance fingerprinting in patients with Parkinson's disease

This study investigated the utility of 3D high resolution magnetic resonance fingerprinting (MRF) to detect potential brain changes in Parkinson’s disease (PD). MRF T1 and T2 maps of the brains of 22 PD patients and 22 volunteers were non-linearly normalized into the MNI space to explore the group differences using whole-brain analysis. PD patients had significantly higher T1 and T2 values in the right inferior temporal gyrus anterior/posterior division, right temporal fusiform cortex anterior division, right planum polare and red nucleus. Our findings suggest that quantitative parameters acquired from 3D MRF may provide additional information for precise diagnosis of PD.