Reproducibility of radiomics features between MRI-derived synthetic-CT and true CT in prostate MR-guided radiotherapy

MR-guided radiotherapy and radiomics have gained considerable attention. Synthetic-CT (sCT) derived from MRI has been adopted to facilitate MRI-only radiotherapy planning. Researches have evaluated the sCT both qualitatively and quantitatively. However, few studies have looked into the potential that sCT offers at radiomics level. We hypothesize that sCT generated from MR can faithfully reproduce radiomics features compared to those extracted from true planning-CT. We aim to investigate the reproducibility of radiomics features derived from a commercially available sCT generation (MRCAT) acquired on a 1.5T MR-simulator to those obtained from a CT simulation scan in a cohort of prostate cancer patients.