The Association of Peritumoral Vasculature Radiomics of Lung Cancer Brain Metastasis with Patient Outcome after Radiosurgery

Gamma Knife radiosurgery (GKRS) is a first-line treatment for brain metastases (BMs) from non-small cell lung cancer (NSCLC). The convolutedness, leakiness and disorganized structure of the peritumoral vasculature have been suggested to be related to the treatment resistance of the tumor. In this study, radiomic features that measure the morphology and spatial organization of peritumoral vasculature were extracted from pre-GKRS MRI. These features were applied to predict overall survival after GKRS in NSCLC-BM patients. We suggested that peritumoral vasculature radiomics could facilitate patient management by identifying potential benefits of GKRS.