Simultaneous in vivo Detection of Cystathionine and 2HG at 7T and Simulation of MEGA and SLOW-editing performance

2-Hydroxyglutarate (2HG) is a biomarker for IDH-mutant glioma, and previous studies have shown that cystathionine (Cys) can be a potential biomarker for 1q/19q co-deletion of glioma. Previous studies used SVS based MEGA-editing MRS to detect 2HG and co-edited Cys, but editing efficiency of Cys is not optimal due to the narrow bandwidth of the applied MEGA editing-pulses. This work shows that SLOW-editing is able to detect both 2HG and Cys in an optimal way with whole-brain coverage.