Lung Multi-Breath Wash in/out MRI with 19F with Sub 0.5 Second Scan Time

We studied the feasibility of multi breath wash-in/out lung acquisition with 19F gas and a sub 0.5 second acquisition spiral sequence. We compared the sub 0.5 seconds acquired data ability to measure wash-in/out time constants to a regular breath-hold 19F lung imaging and report correlation as well as differences in mean. Our results yielded high correlations (r > 0.88) for both wash-in and wash-out time constant calculations. The results indicate our proposed method yield similar calculated time wash-in/out time constants without the need for breath-holds and show promise for the use of free breathing 19F gas lung MRI.