Image- and spectroscopy-based quantitative assessment of renal function using hyperpolarized 13C-labelled Z-OMPD

Fast and accurate assessment of kidney function is crucial for monitoring and detection of kidney disease and failure in various oncological scenarios. Current techniques rely on non‑spatially resolved blood or urine biomarkers and possess time- or safety-related constraints when using MRI or CT. Here, we demonstrate fast 3D bSSFP imaging and slice spectroscopy protocols using hyperpolarized [1,5-13C2]Z-OMPD for assessment of renal perfusion and filtration in comparison with 13C-urea as an established perfusion agent. Measured renal blood flow and glomerular filtration rates agree with literature and between agents and methods, thereby rendering Z-OMPD a versatile agent for assessment of kidney functionality.