Occupational and environmental noise contributes to major public health issues. The chronic high level noise exposure may cause stress and depression and also alterations in Neurometabolites. In-vivo 1H MRS and Open-Field Test are carried out to elucidate the changes in brain metabolite and its effect on behavior due to chronic noise exposure in a preclinical model. A significant increase in Glutamate and N- Acetylaspartate metabolite was observed in hippocampus which is an important target to study the effects of stress. Reduced total movement time, movement distance and mean velocity were observed in the noise exposed group.
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Chauhan et al. (2024) studied this question.
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