Single Shot Diffusion Trace Spectroscopic Imaging using Radial Echo Planar Trajectories

We present the first demonstration of single shot diffusion trace spectroscopic imaging using radial echo planar k-space trajectories on a clinical 3T scanner. Conventional DW-MRS requires three separate acquisitions to compute the trace apparent diffusion coefficient (ADC), whereas the single shot technique generates a trace-weighted signal in one measurement, although this has so far only been applied in NMR and to a limited extent in DW-MRI. Our preliminary results indicate good agreement with expected trace ADC values both in phantom and in healthy brain, showing a promising approach for determining the orientation-independent trace ADC value with non-Cartesian diffusion-weighted spectroscopic imaging.