The evaluation of relationship between motor cortex GABA levels and Gyrification Pattern in Patients With early-onset Parkinson Disease

Stimulation of the motor cortex (MC) significantly reduce akinesia and bradykinesia in Parkinson Disease (PD), indicating a key role of motor cortex abnormalities in the pathogenesis of PD. Early-onset Parkinson disease (EOPD), varying between 40 and 55 years of age, it carries additional societal and personal consequences and psychosocial disruption. Thus we aim to explore the cortical gyrification changes as well as their relationships with r-aminobutyric acid (GABA) in the motor cortex(MC) of patients with early-onset Parkinson disease (EOPD). Results showed that decreased in LGI and GABA+/Cr ratios in the motor cortex were found to be slightly coupled.