Dual-site and dual-vendor comparison of cerebral oxygen extraction fraction by ASE and TRUST MRI in identical participants

We evaluated dual-site and dual-vendor test-retest repeatability and reproducibility of cerebral oxygen extraction fraction (OEF) measured with asymmetric spin echo (ASE) and T2-Relaxation-Under-Spin-Tagging (TRUST) MRI. The intra-site intra-class correlation coefficient (ICC) of global ASE-OEF were 0.952 and 0.919 for each site. The intra-site ICC of TRUST-OEF based on the bovine and the HbA model were 0.810 and 0.792 at site 1, and 0.928 and 0.924 at site 2. The inter-site inter-vendor correlation was 0.849 for ASE-OEF and 0.814 for TRUST-OEF based on the bovine model. ASE-OEF was significantly associated with TRUST-OEF (p<0.001).