Altered amide proton transfer weighted signal in different Suzuki grading and preinfarction period stages in patients with moyamoya disease

To explore the alteration of amide proton transfer weighted (APTw) signal in different Suzuki stages and preinfarction period stages in patients with moyamoya disease (MMD), we enrolled 24 patients who underwent computed tomography perfusion (CTP), digital subtraction angiography (DSA), and APTw imaging. Although our results demonstrated that APTw values in the cerebral hemispheres of MMD patients with Suzuki stages V-VI and preinfarction period stage III are significantly higher than those in other stages, suggesting that the microenvironment of cerebral hemispheres in MMD patients with different Suzuki stages and preinfarction period stages suffers different severity of acidosis penumbra.