Analytical model for determination of exchange times in multi-TE velocity-selective Arterial Spin Labeling

In this work, for the first time, an analytical model for determining the exchange times for obtaining vascular permeability information in velocity-selective Arterial Spin Labeling (VSASL) with multiple echo times (TE) is presented. Signal intensity comparisons were performed between different multi-TE VSASL techniques with each of the standard multi-TE pCASL and multi-TE PASL techniques for different sampling times. This demonstrates that, particularly for longer arterial transit times, the VSASL signal is twice as high compared with standard multi-TE measurements and thus shows promise in the field of non-invasive permeability measurements.