Zooming In: MR and PET Synaptic Density Imaging Techniques in Neuropathology

There are many different modalities to image synaptic density in the brain. The advent of a novel SV2A targeted PET tracer provides the ability to measure in-vivo synaptic density changes in neuropsychiatric disorders. In this education exhibit, we review the current MR and PET-based approaches to synaptic density imaging and present findings from recent animal and human studies of synaptic density changes in neurodegenerative disorders and epilepsy. Our aim is to provide clinicians with the most up-to-date knowledge about imaging techniques of synaptic density that can be integrated into clinical practice.