In this study, the effects of myelin structures such as myelin volume fraction (MVF) and myelin sheath thickness (MST) were investigated by measuring the intra/extracellular water signals in post-mortem aging rat brains. R2 values calculated by intra/extracellular water signals obtained using Carr-Purcell-Meiboom-Gill (CPMG) sequence are theoretically verified by comparison with transmission electron microscopy (TEM) and simulation results. It was confirmed that MVF affects the increase of R2 and MST affects the decrease of R2, and the analysis of R2 through this relationship was statistically significant. These results suggest that effects of myelin structures may affect CPMG-based intra/extracellular water signals.
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Cho et al. (2024) studied this question.
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