7-Tesla in-vivo 1H-magnetic resonance spectroscopy of glutamate and GABA in 22q11.2 copy number variants.

22q11.2 copy number variants (22q11.2 CNVs) are associated with either an increased or a reduced risk of developing psychotic disorders and impaired cognitive functioning. Glutamatergic and GABAergic pathways are hypothesized to be disrupted in 22q11.2 CNV patients. Although a balance between glutamate and GABA is necessary for optimal brain functioning, to date, GABA has not been studied in 22q11.2 CNVs. Here, we investigated glutamate and GABA concentrations in the anterior cingulate cortex in patients with 22q11.2 CNVs using 7-Tesla 1H-MRS. Our results showed no significant differences in glutamate and GABA concentrations between 22q11.2 CNV patients and healthy controls.