Quantitative Assessment of Hyperperfusion using ASL to Predict Hemorrhagic Transformation in Acute Ischemic Stroke Patients

Hemorrhagic transformation (HT) is a potentially life-threatening complication in acute ischemic stroke (AIS) patients. We developed a quantitative of hyperperfusion on ASL and to evaluate its value in the prediction of HT in AIS patients. Our results indicated that CBFmax in hyperperfusion detected on pretreatment ASL was associated with subsequent HT and higher CBFmax was more likely to experience parenchymal hematoma (PH) in AIS patients. The assessment of CBFmax in hyperperfusion on pretreatment ASL may be available in routine clinical practice to further predict subsequent HT and enable timely intervention to prevent PH.