Direct measurement of luminal diffusivity in prostate: Prostate diffusion at an echo time of 400 ms.

We showcase, for the first time, a direct/model-free measurement of luminal diffusivity in prostate, where ADC contrast no longer contains the cellular contribution, and only describes features of the glandular lumen, which prominently shrink with increasing Gleason score. We show that with a 4m30s protocol, the luminal volume fraction, cellular and luminal diffusivities can be obtained with high accuracy/precision at 1.5x1.5x3.0 mm3, suggesting that this approach can feasibly replace the current state-of-the-art, ~6 minute, prostate diffusion acquisition.