Assessment reveals significant time dependency of diffusion parameters in human glioma tissues, highlighting practical selection of diffusion time for evaluating structural heterogeneity.
Recently, diffusion-weighted MRI has emerged for probing intravoxel structural heterogeneity non-invasively as an alternative to gold standard histopathological analysis. A previous study demonstrated the correlation between the imaging- and histology-based tissue heterogeneities using a continuous-time random-walk (CTRW) model at a single diffusion time. In this study, we extended the study to multiple diffusion times and investigated the diffusion time dependence of the CTRW parameters and their correlation with histology-based heterogeneity on human glioma tissues. Significant time dependency was observed in the CTRW parameters, providing practical insights into the selection of diffusion time when assessing tissue heterogeneity.
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Dan et al. (2024) studied this question.
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