Quantitative analysis of metabolites in mouse optical track after severe traumatic brain injury using magnetic resonance spectroscopy

Traumatic brain injury (TBI) is associated with an increased risk of cognitive and neurodegenerative complications that may develop and persist years after injury. Altered metabolism is considered to be the earliest possible sign of tissue injury and will be present before any structural changes can be detected. Magnetic resonance spectroscopy is a useful technology for longitudinal assessments, which are critical for understanding altered neurochemical concentrations following TBI, suggesting impaired neurotransmission and energy generation, neuronal injury/death, and oxidative stress