Comparability of mcTFI QSM and 2D GRE CMB Detection: Implications for for Alzheimer’s Anti-Amyloid Therapy

This is the authors' abstract. We don't add key points for this paper.

Cerebral microbleeds/microhemorrhages (CMB) are used for risk stratification, including for the hemorrhagic complication ARIA-H of Alzheimer’s anti-amyloid therapy. For AD, risk information is based on many trials using 2DGRE technique, which is MRI field and parameter dependent. The use of techniques that better distinguish CMB mimics, like calcifications, is limited by an unclear relationship to 2D GRE CMB depiction. In this study we found the number of CMB candidate lesions between 2D GRE and mcTFI QSM obtained during the same scan session highly correlated, suggesting mcTFI could be used in the management of pathologies evaluating presence and number of CMBs.