We compared the novel DWI MRI-based metabolic activity [MA] imaging approach [MADI] to 18FDG-PET, employing an in vivo rat glioma model. The MADI-derived parameter, kio*V product, is proportional to Na+/K+ ATPase [NKA] activity, the primary cellular energy consumer. The kioV decreased within the tumor vs. contralateral while 18FDG uptake increased. This is consistent with the Warburg effect in glioma, which activates glucose uptake but also switches energy production from mitochondrial oxidative phosphorylation to glycolysis, thus reducing overall ATP production and NKA activity. MADI expands DWI MRI utility, providing a novel, noninvasive MA imaging method, with greater resolution than PET.
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Schlegel et al. (2024) studied this question.
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