Increasing evidence showed subtle cerebrovascular reactivity (CVR) impairment in neurodegenerative disease. In the longitudinal study herein, we aimed to investigate regional CVR changes in the patients with Parkinson’s disease (PD) at baseline and 2 years follow up, and CVR was derived from resting state fmri scans. PD patients showed significantly reduced CVR in the left inferior occipital gyrus and right superior temporal cortex. In addition, the reduction of CVR may associate with executive function deficits. Our results also showed that there was a tendency for functional connectivity to be weakened from posterior to anterior with the progression of the disease.
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Li et al. (2024) studied this question.
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