DCE-MRI in Distinguishing Solitary Brain Metastasis from Glioblastoma: Evaluation of Multiple Pharmacokinetic Models

This study aimed to explore performances of parameters derived from DCE-MRI with multiple pharmacokinetic models regarding this differential diagnosis, as well as overall performances of models. Eighty-eight patients with suspected GBM and SBM underwent DCE-MRI in this study. Peritumoral vp from shutter-speed model achieved the best single-parameter’s performance. Additionally, shutter-speed model achieved the highest overall separating performance. Shutter-speed is the recommended DCE-MRI pharmacokinetic model for differential diagnosis between GBM and SBM.