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The neurochemical substrate of the measures observed with transcranial magnetic stimulation remains unclear. MR spectroscopy may provide valuable insights into understanding the synaptic GABAergic and glutamatergic activity, however studies comparing these methods haven’t provided an adequate explanation. We aimed to compare GABA and glutamate concentrations with short-interval afferent inhibition measured with TMS. We found positive correlation between the amount of inhibition and tonic GABA levels, however this finding needs to be carefully scrutinized.
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Považan et al. (2024) studied this question.
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