Comparison of ventilation defects quantified by Technegas V-SPECT and hyperpolarized 129Xe MRI

Previous studies have demonstrated the comparability of ventilation assessed by SPECT and hyperpolarized gas MRI methods; however, these comparisons were qualitative and limited to visual scoring methods based on radiologist reporting. Thus, we quantified the relationship between ventilation-defect-percent (VDP) assessed from same-day Technegas ventilation-SPECT and hyperpolarized 129Xe MRI, in patients with early-stage lung cancer. We observed that ventilation defects quantified by Technegas V-SPECT and 129Xe MRI VDP were correlated and increased in patients with COPD. A bias towards higher Technegas V-SPECT VDP was detected and may be explained by differences in contrast agent properties, image acquisition conditions, and/or quantification pipelines.