MRI measured Neuroanatomic volume, Cortical Thinning and WMH load with Aging: The Early, Intermediate and Late events of Cognitive status

The key to understanding brain-biomarkers depictive of normal cognition and cognitive impairment due to MCI (CI) and/or Alzheimer’s disease (CI-AD) is to identify the series of early, intermediate, and late events that encode brain health. The temporal and spatial order of events of brain health changes observed on MRI, associated with normal aging needs to be precisely delineated from the events associated with cognitive impairment. We have identified early, intermediate and late brain structural and microvascular events distinctive of CN, CI and CI-AD and developed an AI-based platform using an optimal number of MRI features distinctive of cognitive status.