R2* is highly sensitive not only to tissue iron level, but also to the microscopic iron distribution. In this study, we first characterize the distribution of R2* within the deep brain nuclei in Parkinson's disease patients and health controls, especially the lateral difference. Secondly, we also evaluate the clinical usefulness of regional R2* for the differential diagnosis between PD and HC group. The results showed that there was no lateral difference in R2* values in the HC and PD groups. The R2* value of the right thalamus in the HC group was statistically higher than that in the PD group.
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Wang et al. (2024) studied this question.
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