Comparative analysis reveals dose-dependent hippocampal and white matter damage in adult childhood cancer survivors, highlighting neuroimaging biomarkers of cognitive deficits.
Cranial radiotherapy (CRT) is effective; however, survivors of childhood cancer often suffer from cognitive deficits. Two adult patient groups that received different CRT exposures as children were included, as well as healthy volunteers. The MR-examination comprised of anatomical imaging, DTI and MR spectroscopy of the hippocampus. Differences were found between the group that received highest CRT dose and the control group in hippocampal volume, tNAA/tCr-ratio of hippocampus and several DTI-measures in e.g., corpus callosum. Correlations was found between DTI-measures (MD/RD/AD) in some of the studied white matter tracts and several of the used neuropsychological tests, e.g., BVMT-R Sum and Coding.
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Ljungberg et al. (2024) studied this question.
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