Micro Fiber Disruption and Thalamus GABA Level Reduction in Lifelong Premature Ejaculation

In this study, we using non invasion GABA-edited MEGA-PRESS MRS and NODDI model to measure the GABA content in bilateral thalamus and the water diffusion pattern in premature ejaculation patient. The PE patients have more dispersed neurites in the right putamen, more hindered water, and less space within axons in the orbitofrontal cortex. The bilateral thalamus GABA content in PE group is significantly lower than NC group. These findings may help us have a better neuroimage upstanding of PE from micro-structure to metabolism level.