Left Ventricular Vertical Run-Length Non-Uniformity Adds Prognostic Value to MACE in Patients with ESRD

Left ventricular vertical run-length non-uniformity (VRLN) represents heterogeneity within native T1 images and reflects the extent of cardiac fibrosis. In uremic cardiomyopathy, interstitial fibrosis was found to be the major histological alteration. The aim of this study was to evaluate the prognostic value of VRLN in patients with ESRD. The primary endpoint was major adverse cardiac events (MACE). Survival analysis was calculated by Kaplan-Meier curves with log-rank test. VRLN remained associated with MACE in the multivariable model. Adding VRLN to a model containing clinical and CMR parameters significantly improved the accuracy and reclassification of the predictive model.