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The regional characteristics extracted from myelin-related images have been considered the markers of brain degradation. However, a systematic investigation of age-dependent changes in myelin-related images remains deficient. We aimed to investigate the associations between regional features and age in myelin-related images. Our results revealed that ADC, mFLAIR, and T1w/T2w ratio were associated with age while aMWF showed no age-dependency. The increased heterogeneity and decreased uniformity in certain brain regions were observed in the elderly, indicating changes of microstructural tissue integrity in ADC, mFLAIR, and T1w/T2w ratio and the clinical usefulness of aMWF without a confounding factor of age in diagnosis.
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Chen et al. (2024) studied this question.
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