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A fingerprinting sequence was developed with and without off resonance pulses before every TR to investigate MT effects on T1 and T2 values. Off-resonance pulses suppress MT effects by saturating signal from free protons that exchange with bound protons. Observed T2 values increased with off resonance pulses as expected. Observed T1 values decreased, this was an opposite effect to what was observed previously with a different pulse sequence.
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Kukran et al. (2024) studied this question.
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