Hyperpolarized 129Xe MRI ventilation textures predict short- and long-term response to Anti-IL-5Rα Biologic Therapy in Eosinophilic Asthma

It was previously shown that 129Xe MR ventilation images contain embedded texture features which help predict (before treatment was initiated) those severe asthma patients who were more likely to experience early response to anti-IL-5Rα biologic therapy. Thus, we postulated that such texture features would also help identify patients with an enduring, late response. Here we identified specific 129Xe MRI features that predicted both early and late response to anti-IL-5 therapy, which were superior to clinical measurements. These promising results suggest that 129Xe MRI texture features sensitively predict patients with response to biologic therapy interventions.