A complete cerebellar mean-field model ready to be integrated into whole-brain dynamic simulators

Whole-brain dynamics can be reproduced in silico by simulating Blood Oxygen Level Dependent (BOLD) signals, typically recorded with fMRI, using cortical and subcortical mean-field models, which provide a population-level description of the underlying neuronal dynamics. Notably, a mean-field model specific for the cerebellum is missing given its structural and functional specific properties. We present the first biologically-grounded cerebellar mean-field model optimized on experimental data. Our model reproduces cerebellar activity and synaptic mechanisms characterizing physiological and pathological conditions. The cerebellar mean-field model is a new device ready to be integrated in whole-brain dynamic simulator, improving understanding of brain function and dysfunction.