Dynamic lung water imaging during exercise stress

Dynamic quantification of lung water during exercise stress is of clinical interest for early diagnosis of heart failure. In this study, we demonstrate a method to derive quantitative time-resolved lung water density maps from a continuous 3D MRI acquisition during supine exercise stress by using a motion corrected sliding-window image reconstruction. An animal model of dynamic lung water accumulation was used to validate the method, and feasibility was demonstrated in healthy subjects imaged in transitions between rest and exercise, measuring a lung water density increase of 23±10% during peak exercise.