This study examined changes in diffusion tensor parameters during amyotrophic lateral sclerosis progression using a transgenic rodent model. DTI was performed at four timepoints with an even amount of male and female rats to probe sex differences. Leg muscles were excised following scanning for histological analysis. Sex had a statistically significant effect on all parameters. Mean, radial, and axial diffusivity as well as the second eigenvalue were the most sensitive markers of disease progression.
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Mathew et al. (2024) studied this question.
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