Modeling Mouse Placental Perfusion Dynamics and Contractions via Dynamic Contrast Enhancement MRI

Placental development is a dynamic process, and the timing of placental development events is crucial for appropriate fetal development. However, the placenta itself remains critically understudied in the context of fetal development disorders. We propose novel models for correlating DCE-MRI perfusion estimation with biologically relevant compartments and extracting dynamic biomarkers for placental development. We validate this model by demonstrating that placental perfusion is disrupted in a murine model of peri-conceptual alcohol exposure, and that this disruption occurs differently across various compartments from E14.5 to E17.5.