In vitro study uncovers mechanical stretch as a trigger of lung epithelial cell senescence, suggesting a pathway linking mechanical ventilation to secondary lung fibrosis.
Severe lung injury requiring mechanical ventilation may lead to secondary fibrosis. Senescence, a cell response characterized by cell cycle arrest and a shift towards a proinflammatory/profibrotic phenotype, is one of the involved mechanisms. Here, we explore the contribution of mechanical stretch as trigger of senescence of the respiratory epithelium and its link with fibrosis. Human lung epithelial cells and fibroblasts were exposed
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Martín-Vicente et al. (2024) studied this question.
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