The hydrophobic core of a protein, made up of side chains buried away from water in the folded state, is a crucial element of protein structure. New results show that artificial backbone connectivity can be accommodated in the core of a tertiary fold with minimal impact on folded structure or stability. More information can be found in the Research Article by Y. Lin and W. S. Horne (DOI: 10.1002/chem.202401890).
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