The Adaptive Mechanism of Liver in Response to Hyperglycemic Functional Stress in Alloxan Induced Diabetes

Background: Diabetes is a common disease that poses significant medical and socio-economic challenges due to its widespread prevalence and its impact on disability and life expectancy. Recent studies have demonstrated a reduction in high-ploidy (2c×2) hepatocytes within one month of injecting Alloxan or Streptozotocin in experimental models of diabetes mellitus. This phenomenon is attributed to decreased insulin levels, which regulate cytokinesis and consequently affect the number of high-ploidy cells during cytoskeletal reorganization. However, the dynamics between diploid and high-ploidy cells during the initial phase of the disease (within the first 48 hours), characterized by extreme changes in glucose concentration, have not been thoroughly investigated. This study aims to explore the liver's adaptive responses to hyperglycemic stress during the early stages of diabetes.