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August 9, 2024ACS Applied Bio Materials

PEGylated Pemetrexed and PolyNIPAM Decorated Gold Nanoparticles: A Biocompatible and Highly Stable CT Contrast Agent for Cancer Imaging

Mohammad Mohajeri Peyman Salehi Bahareh Heidari Hasan Rafati S. Mohsen Asghari Hossein Behboudi Pooya Iranpour

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Abstract

This study describes a multifunctional nanoparticle platform for targeted CT imaging and therapy of cancers. Pemetrexed (conjugated with polyethylene glycol, MW 2000 Da) and polyNIPAM (PEGylated) were designed for targeted delivery to folate receptors and thermally ablated tumors, respectively. These moieties were coated on gold nanoparticles (7 and 30 nm), and the prepared compounds were characterized using

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Mohajeri et al. (2024) studied this question.

synapsesocial.com/papers/68e5cda6b6db6435875638cd https://doi.org/10.1021/acsabm.4c00563

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