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August 9, 2024Anesthesiology

Neuropeptide Y Y2 Receptors in Sensory Neurons Tonically Suppress Nociception and Itch but Facilitate Postsurgical and Neuropathic Pain Hypersensitivity

Paramita Basu Akshitha Maddula Tyler S. Nelson Pranav Prasoon Michelle K. Winter Herbert Herzog Kenneth E. McCarson Bradley K. Taylor

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Abstract

Neuropeptide Y (NPY) Y2 receptor (Y2) antagonist BIIE0246 can both inhibit and facilitate nociception. The authors hypothesized that Y2 function depends on inflammation or nerve injury status.

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Cite This Study

Basu et al. (2024) studied this question.

synapsesocial.com/papers/68e5cdb1b6db6435875639a3 https://doi.org/10.1097/aln.0000000000005184

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The pharmacotherapeutic potential of neuropeptide Y for chronic pain2025 · 12 citations
2Selective Mediation of Nerve Injury-Induced Tactile Hypersensitivity by Neuropeptide YOriginal Research · 2002 · 109 citations
3Neuropeptide Y neurons mediate opioid-induced itch by disinhibiting GRP-GRPR microcircuits in the spinal cord2025 · 15 citations
4Neuropeptide Y: Direct vasoconstrictor and facilitatory effects on P2X1 receptor-dependent vasoconstriction in human small abdominal arteriesOriginal Research · 2023 · 9 citations
5Structural basis of neuropeptide Y signaling through Y<sub>1</sub> and Y<sub>2</sub> receptors2024 · 7 citations

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